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Intern Med. 2019 Apr 1;58(7):933-936. doi: 10.2169/internalmedicine.1838-18. Epub 2018 Dec 18.

Glossopharyngeal Neuralgia with Syncope Caused by Recurrence of Esophageal Squamous Cell Carcinoma.

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Third Department of Internal Medicine, Toyama University Hospital, Japan.
Toyama Red Cross Hospital, Japan.


We herein report a case of glossopharyngeal neuralgia with repeated syncope caused by the recurrence of esophageal carcinoma. The typical symptoms of glossopharyngeal neuralgia are paroxysmal, stabbing, electric shock-like pain in the pharynx and/or base of the tongue on swallowing and talking. In addition, syncope can also be caused by glossopharyngeal neuralgia. The diagnosis of glossopharyngeal neuralgia is not always easy because of its rarity. In the present case, we suspected that repeated syncope was caused by glossopharyngeal neuralgia due to the recurrence of esophageal carcinoma. Concurrent chemoradiation therapy was effective in reducing the tumor size, which resulted in the complete resolution of the symptoms.


esophageal carcinoma; glossopharyngeal neuralgia; syncope

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