Format

Send to

Choose Destination
Genes Dev. 2019 Jan 1;33(1-2):55-60. doi: 10.1101/gad.319939.118. Epub 2018 Dec 19.

PRC1 preserves epidermal tissue integrity independently of PRC2.

Author information

1
Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
2
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
3
California Academy of Sciences, San Francisco, California 94118, USA.
4
Department of Frontier Research and Development, Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan.
5
Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS) Tsurumi-ku, Yokohama 230-0045, Japan.
6
Advanced Research and Development Programs for Medical Innovation (AMED-CREST), Tsurumi-ku, Yokohama 230-0045, Japan.
7
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
8
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases.

KEYWORDS:

PRC1; PRC2; Polycomb complex; cell adhesion; epidermis; epigenetics; skin

PMID:
30567998
PMCID:
PMC6317312
DOI:
10.1101/gad.319939.118
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center