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Br J Psychiatry. 2018 Dec 20:1-5. doi: 10.1192/bjp.2018.270. [Epub ahead of print]

Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population.

Author information

1
Assistant Professor,School of Life Science and Engineering,Southwest Jiaotong University,China.
2
Candidate,Brainnetome Center and National Laboratory of Pattern Recognition,Institute of Automation, University of Chinese Academy of Sciences,China.
3
Professor,Brainnetome Center and National Laboratory of Pattern Recognition,Institute of Automation, University of Chinese Academy of Sciences, China; The Mind Research Network, USA; and CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences,China.
4
Professor,National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Science and Peking Union Medical College,Tsinghua University,China.
5
Professor,Wuxi Mental Health Center,Nanjing Medical University,China.

Abstract

BACKGROUND:

Our previous genome-wide association study (CONVERGE sample) identified significant association between single nucleotide polymorphisms (SNPs) near the SIRT1 gene and major depressive disorder (MDD) in Chinese populations.AimsTo investigate whether SNPs across the SIRT1 gene locus affect regional grey matter density in the Han Chinese population.

METHOD:

T1-weighted structural magnetic resonance imaging was conducted on 92 healthy participants from Eastern China. Grey matter was segmented from the image, which consisted of voxel-wise grey matter density. The effect of SIRT1 SNPs on grey matter density was determined by a multiple linear regression framework.

RESULTS:

SNP rs4746720 was significantly associated with grey matter density in two brain cortical regions: the orbital part of the right inferior frontal gyrus and the orbital part of the left inferior frontal gyrus (family-wise error-corrected P < 0.05; voxel-wise P < 0.001). Also, rs4746720 exceeded genome-wide significance in association with MDD in our CONVERGE sample (P = 3.32 × 10-08, odds ratio 1.161).

CONCLUSIONS:

Our results provided evidence for a potential role of the SIRT1 gene in the brain, implying a possible pathophysiological mechanism underlying susceptibility to MDD.Declaration of interestNone.

KEYWORDS:

SIRT1; grey matter density; sMRI

PMID:
30567608
DOI:
10.1192/bjp.2018.270

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