Format

Send to

Choose Destination
Nutrients. 2018 Dec 18;10(12). pii: E2000. doi: 10.3390/nu10122000.

Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.

Author information

1
Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain. almudena.sanchez@ulpgc.es.
2
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. almudena.sanchez@ulpgc.es.
3
Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain. jackyalvarez62@gmail.com.
4
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. jackyalvarez62@gmail.com.
5
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. etoledo@unav.es.
6
Department of Preventive Medicine and Public Health, University of Navarra-IdiSNA, 31008 Pamplona, Spain. etoledo@unav.es.
7
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. jordi.salas@urv.cat.
8
Department of Biochemistry and Biotechnology, Human Nutrition Unit, Universitat Rovira i Virgili, 43204 Reus, Spain. jordi.salas@urv.cat.
9
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain. jordi.salas@urv.cat.
10
Department of Internal Medicine. University Hospital of Sant Joan de Reus, 43204 Reus, Spain. jordi.salas@urv.cat.
11
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. carolina.ortega@uv.es.
12
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain. carolina.ortega@uv.es.
13
Cardiovascular Risk and Nutrition, IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain. mariadoloreszf@blanquerna.edu.
14
Blanquerna School of Life Sciences, Universitat Ramon Llull, 08025 Barcelona, Spain. mariadoloreszf@blanquerna.edu.
15
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. vioque@umh.es.
16
Nutritional Epidemiology Unit, Miguel Hernández University, ISABIAL-FISABIO, 46020 Alicante, Spain. vioque@umh.es.
17
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. jalfmtz@unav.es.
18
IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain. jalfmtz@unav.es.
19
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. d.romaguera-bosch@imperial.ac.uk.
20
Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, 07120 Palma de Mallorca, Spain. d.romaguera-bosch@imperial.ac.uk.
21
School of Health Sciences. University of Málaga-IBIMA, 29010 Malaga, Spain. jwarnberg@uma.es.
22
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. jlopezmir@gmail.com.
23
Department of Internal Medicine, Reina Sofia University Hospital, University of Córdoba-IMIBIC, 14004 Córdoba, Spain. jlopezmir@gmail.com.
24
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. restruch@clinic.cat.
25
Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. restruch@clinic.cat.
26
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. abueno@ugr.es.
27
Department of Preventive Medicine, University of Granada, 18016 Granada, Spain. abueno@ugr.es.
28
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. aborau@secardiologia.es.
29
Department of Cardiology OSI ARABA, University Hospital Araba, 01009 Vitoria, Spain. aborau@secardiologia.es.
30
Department of Medicine, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. aborau@secardiologia.es.
31
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. pep.tur@uib.es.
32
Research Group on Community Nutrition and Oxidative Stress, Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain. pep.tur@uib.es.
33
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. fjtinahones@uma.es.
34
School of Health Sciences. University of Málaga-IBIMA, 29010 Malaga, Spain. fjtinahones@uma.es.
35
Department of Endocrinology, University Hospital, University of Málaga, 29010 Málaga, Spain. fjtinahones@uma.es.
36
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. oscar.lecea.juarez@cfnavarra.es.
37
Department of Preventive Medicine and Public Health, University of Navarra-IdiSNA, 31008 Pamplona, Spain. oscar.lecea.juarez@cfnavarra.es.
38
Atención Primaria, Osasunbidea-Servicio Navarro de Salud, 31002 Pamplona, Spain. oscar.lecea.juarez@cfnavarra.es.
39
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. vicente.martin@unileon.es.
40
Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain. vicente.martin@unileon.es.
41
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. mortega7@us.es.
42
Department of Family Medicine, Distrito Sanitario Atencion Primaria, Centro de Salud Las Palmeritas, 41005 Sevilla, Spain. mortega7@us.es.
43
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. cvazquezma@gmail.com.
44
Department of Endocrinology, Fundación Jiménez-Díaz, 28040 Madrid, Spain. cvazquezma@gmail.com.
45
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. xpinto@bellvitgehospital.cat.
46
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, 08907 Barcelona, Spain. xpinto@bellvitgehospital.cat.
47
Consorcio CIBER, M.P. Diabetes y enfermedades metabólicas (CIBERDem), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. jovidal@clinic.cat.
48
Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. jovidal@clinic.cat.
49
IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain. lidia.daimiel@imdea.org.
50
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. mdelgado@ujaen.es.
51
Division of Preventive Medicine, University of Jaén, 23071 Jaén, Spain. mdelgado@ujaen.es.
52
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain. pilar.matia@gmail.com.
53
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. dolores.corella@uv.es.
54
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain. dolores.corella@uv.es.
55
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. andres.diaz@urv.cat.
56
Department of Biochemistry and Biotechnology, Human Nutrition Unit, Universitat Rovira i Virgili, 43204 Reus, Spain. andres.diaz@urv.cat.
57
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain. andres.diaz@urv.cat.
58
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. nancy.babio@urv.cat.
59
Department of Biochemistry and Biotechnology, Human Nutrition Unit, Universitat Rovira i Virgili, 43204 Reus, Spain. nancy.babio@urv.cat.
60
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain. nancy.babio@urv.cat.
61
Primary Health Care Division. Institut Català de la Salut and IDIAPJgol, 08007 Barcelona, Spain. mamunoz.bcn.ics@gencat.cat.
62
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. mfito@imim.es.
63
Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), 08003 Barcelona, Spain. mfito@imim.es.
64
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. manoli@umh.es.
65
Nutritional Epidemiology Unit, Miguel Hernández University, ISABIAL-FISABIO, 46020 Alicante, Spain. manoli@umh.es.
66
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain. iabetego@unav.es.
67
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. angarios2004@yahoo.es.
68
Department of Internal Medicine, Reina Sofia University Hospital, University of Córdoba-IMIBIC, 14004 Córdoba, Spain. angarios2004@yahoo.es.
69
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. eros@clinic.cat.
70
Primary Health Care Division. Institut Català de la Salut and IDIAPJgol, 08007 Barcelona, Spain. eros@clinic.cat.
71
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. mcanela@unav.es.
72
Department of Preventive Medicine and Public Health, University of Navarra-IdiSNA, 31008 Pamplona, Spain. mcanela@unav.es.
73
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. mamartinez@unav.es.
74
Department of Preventive Medicine and Public Health, University of Navarra-IdiSNA, 31008 Pamplona, Spain. mamartinez@unav.es.
75
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. mamartinez@unav.es.
76
Ecoaqua Institute, University of Las Palmas de Gran Canaria, 35214 Telde, Spain. marisol.izquierdo@ulpgc.es.
77
Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain. lluis.serra@ulpgc.es.
78
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. lluis.serra@ulpgc.es.

Abstract

BACKGROUND:

The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence.

METHODS:

Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms.

RESULTS:

Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression.

CONCLUSION:

In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.

KEYWORDS:

depression; docosahexaenoic acid; eicosapentaenoic acid; fish; omega-3

PMID:
30567286
PMCID:
PMC6315981
DOI:
10.3390/nu10122000
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center