Format

Send to

Choose Destination
Nanomedicine (Lond). 2019 Jan;14(2):183-199. doi: 10.2217/nnm-2018-0150. Epub 2018 Dec 19.

Specific capture and release of circulating tumor cells using a multifunctional nanofiber-integrated microfluidic chip.

Author information

1
State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, China.
2
Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.

Abstract

AIM:

To develop a multifunctional nanofibrous mat-embedded microfluidic chip system for specific capture and intact release of circulating tumor cells.

MATERIALS & METHODS:

Electrospun polyethylenimine/polyvinyl alcohol nanofibers were functionalized with zwitterions to reduce the nonspecific adhesion of blood cells, followed by modification with arginine-glycine-aspartic acid peptide via an acid-sensitive benzoic imine bond.

RESULTS:

The nanofiber-embedded microchip can be applied for capturing various types of cancer cells and circulating tumor cells with high efficiency and considerable purity. The captured cancer cells can be released from the nanofibrous substrates within 30 min.

CONCLUSION:

The developed multifunctional nanofiber-embedded microfluidic chip may have a great potential for clinical applications.

KEYWORDS:

circulating tumor cells; electrospun nanofibers; intact release; microfluidic chip; zwitterion

PMID:
30566024
DOI:
10.2217/nnm-2018-0150

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center