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Clin Case Rep. 2018 Oct 26;6(12):2416-2423. doi: 10.1002/ccr3.1877. eCollection 2018 Dec.

An unusual presentation of a patient with severe hypogammaglobulinemia.

Author information

1
Department of Pulmonology St. Antonius Hospital Nieuwegein The Netherlands.
2
Division of Heart and Lungs University Medical Center Utrecht Utrecht The Netherlands.
3
Department of Pediatrics Leiden University Medical Center Leiden The Netherlands.
4
Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center University of Amsterdam Amsterdam The Netherlands.
5
Department of Medical Microbiology and Immunology St. Antonius Hospital Nieuwegein The Netherlands.
6
Department of Science University College Roosevelt Middelburg The Netherlands.

Abstract

We present a patient who was diagnosed with severe hypogammaglobulinemia after her newborn child presented with two episodes of meningitis. The patient had no history or symptoms suggestive of immunodeficiency. Thus far, a cause for the immunodeficiency has not been found, even after extensive immunological evaluation.

KEYWORDS:

antibody replacement therapy; hypogammaglobulinemia; immunodeficiency; primary antibody deficiency; vaccination response

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