Format

Send to

Choose Destination
Mar Drugs. 2018 Dec 17;16(12). pii: E513. doi: 10.3390/md16120513.

Bromopyrrole Alkaloids from the Sponge Agelas kosrae.

Author information

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. ideally225@snu.ac.kr.
2
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. kdh9298@gmail.com.
3
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. hqhqeori@snu.ac.kr.
4
Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, P.O. Box 29, Seoul 425-600, Korea. yjlee@kiost.ac.kr.
5
Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, P.O. Box 29, Seoul 425-600, Korea. hslee@kiost.ac.kr.
6
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea. cjsim@hnu.kr.
7
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
8
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. sklee61@snu.ac.kr.
9
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. ohkibong@snu.ac.kr.
10
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.

Abstract

Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.

KEYWORDS:

anti-angiogenesis; bioactive marine natural products; isocitrate lyase; marine sponge; pyrrole-imidazole alkaloids; sceptrin

PMID:
30563015
PMCID:
PMC6316234
DOI:
10.3390/md16120513
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center