Send to

Choose Destination
Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Dec 18;50(6):1009-1013.

[Multidisciplinary classification of magnetic resonance imaging features of neuropsychiatric lupus].

[Article in Chinese]

Author information

Department of Rheumatology and Immunology, Handan Hospital of Traditional Chinese Medicine, Handan 056001, Hebei, China.
Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.



To investigate the clinical correlation between the manifestations of neuropsychiatric lupus (NPSLE) and brain magnetic resonance imaging (MRI).


Retrospective analysis of 65 neuropsychiatric lupus patients with brain MRI and clinical data from Peking University Third Hospital from January 2006 to October 2016, which was classified by rheumatologist, neurologists, and radiologists based on their brain MRI findings. The correlation between brain MRI findings and clinical manifestations was analyzed.


The characteristics of the brain MRI of the 65 patients were divided into 6 categories: 16 cases (25%) with demyelination in the white matter, 15 cases (23%) with cerebrovascular disease, including 4 cases (6%) with large vascular disease and 11 cases (17%) with small vessel disease, 4 cases (6%) with inflammation, 4 cases (6%) with edema, 13 cases (20%) with multiple manifestation coexistence, and 13 cases (20%) without any abnormality. Except for 4 cases of brain MRI with edema, the clinical manifestations were only epileptic seizures, other patients had complex and diverse clinical manifestations, including epileptic seizures, lupus-like headaches, mental symptoms, blurred vision, peripheral neuropathy and disturbance of consciousness. The incidence of epileptic seizures in patients with edema of MRI is significantly higher than that of other patients, and the therapeutic response time is the shortest.


Multidisciplinary collaboration divides the MRI findings of neuropsychiatric lupus patients into six categories. This classification method helps clinicians to predict and intervene early possible neuropsychiatric symptoms to guide clinical treatment.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Journal of Peking University (Health Sciences)
Loading ...
Support Center