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Dev Cell. 2018 Dec 17;47(6):691-693. doi: 10.1016/j.devcel.2018.11.038.

CD44 Orchestrates Metastatic Teamwork.

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The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, UNSW Medicine, UNSW Sydney, Australia. Electronic address:
INSERM UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Electronic address:


Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.

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