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J Pediatr Gastroenterol Nutr. 2018 Dec 14. doi: 10.1097/MPG.0000000000002236. [Epub ahead of print]

Experience of Using A Semi-Elemental Formula For Home Enteral Nutrition In Children: A Multicenter Cross-Sectional Study.

Author information

1
Department of pediatric gastroenterology, hepatology and nutrition, CHU Lille, University Lille, F-59000, France.
2
Université Libre de Bruxelles, B-1050, Belgium.
3
Gastroenterology, Department of pediatrics, CHU Nantes, F-44093, France.
4
University Toulouse, INSERM, INRA, ENVT, UPS, F-31330 Toulouse, France.
5
Department of pediatric gastroenterology, hepatology, nutrition, diabetology and inherited metabolic disorders, Children Hospital, CHU Toulouse, F-31300, France.
6
Department of pediatric gastroenterology, Hôpital Necker - Enfants Malades, F-75015 Paris, France.
7
Department of pediatric hepatology, gastroenterology and nutrition, CHU Besançon, F-25030, France.
8
Nutrition and Gastroenterology, Department of Pediatrics, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, F-69002, France.
9
Department of pediatrics, CHU Clermont-Ferrand, F-63100, France.
10
Department of pediatric gastroenterology and nutrition, Hôpital Robert-Debré, F-75019 Paris, France.
11
Pediatric hepatology and gastroenterology, Department of pediatrics, CHU Marseille, F-13005, France.
12
Pediatric gastroenterology, Department of pediatrics, CHU Bordeaux, F-33000, France.
13
Pediatric hepatology and gastroenterologie, Department of pediatrics, CHU Grenoble, F-38700, France.
14
Department of pediatrics, CHU Felix Guyon, F-97400, La Réunion, France.
15
Department of pediatric nutrition and gastroenterology, Hôpital Trousseau, F-75012 Paris, France.
16
Gastroenterology and hepatology, Department of pediatrics, CHU Rennes, F-35033, France.
17
Nestlé Health Science, France.
18
Engineer in biostatistics, University Lille, CHU Lille, F-59000 Lille, France.

Abstract

OBJECTIVES:

The use of semi-elemental diets concerns a small proportion of children on enteral nutrition whose characteristics have never been reported. Our aim was to describe a cohort of patients on home enteral nutrition with Peptamen Junior, including the tolerance and nutritional efficacy of this product.

METHODS:

We performed a retrospective multicenter survey on a cohort of patients receiving this semi-elemental diet at home between 2010 and 2015 in 14 tertiary pediatric French centers. We recorded at baseline, 3, 6 and 12 months, and then every year the anthropometric characteristics of the patients, indications and modalities of administration of the diet, and the tolerance and adverse events.

RESULTS:

We recruited 136 patients aged 9.8 ± 4.4 years at baseline. Mean BMI z-score was -1.0 ± 1.8; mean height z-score was -1.1 ± 1.9. The main underlying diseases were digestive (35.3%), neurological (33.1%), and haematological (19.9%). The indications for a semi-elemental diet were failure of another diet in 70 patients (51.9%), severe malnutrition in 19 (14.1%), cystic fibrosis in 11 (8.1%) and switch from parenteral nutrition in 11 (8.1%). Side effects were observed in 39.2% of the patients, and required medical attention in 8.2%. Body mass index improved or remained normal in 88.3% of children.

CONCLUSIONS:

This semi-elemental diet seems to be well tolerated and efficient in the setting of home enteral nutrition in children with complex diseases featuring malabsorption and/or after failure of polymeric diet.

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