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J Infect Dis. 2019 Jun 5;220(1):68-72. doi: 10.1093/infdis/jiy663.

Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals.

Author information

1
Department of Neurology, Washington University in Saint Louis, Missouri.
2
Department of Radiology, Washington University in Saint Louis, Missouri.
3
Hope Center, Washington University in Saint Louis, Missouri.

Abstract

Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.

KEYWORDS:

Alzheimer’s disease; HIV dementia; positron emission tomography

PMID:
30561665
PMCID:
PMC6548892
[Available on 2020-06-05]
DOI:
10.1093/infdis/jiy663

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