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Rev Neurol. 2019 Jan 1;68(1):1-6.

[Candida spp. in the gut microbiota of people with autism: a systematic review].

[Article in Spanish; Abstract available in Spanish from the publisher]

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Universidad de Murcia, 30071 Murcia, Espana.
Universidad de Alicante, 03080 Alicante, Espana.


in English, Spanish


There is great interest in studies on the implications that gut microbiota exerts on the behavior of people with autism spectrum disorders (ASD), through the microbiota-gut-brain axis. Most studies on microbiota are focused on the possible involvement of bacteria on people with ASD, but few of them are focussed on the effect of microorganisms in the Fungi kingdom.


The present study performs a systematic review of the presence of Candida spp. in people with ASD using the PRISMA method.


A total of three articles were found after applying the exclusion and inclusion criteria of the systematic review. Two studies coincided in reporting significant differences in the increase in the frequency of the Candida spp. genus in people with ASD. while the third study did not report significant differences of Candida spp. genus between people with ASD.


Although there is a clear lack of investigation of both the Candida ssp. genus and the whole Fungi kingdom in people with ASD, the studies point to an important presence of this genre in this group. Specifically, in the results found in this review, the highest prevalence of the C. albicans in children with ASD stands out. However, little is still known about the involvement of Candida spp., and other types of fungi, on gastrointestinal symptoms and ASD symptoms, in children with ASD.

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