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Aging Cell. 2019 Feb;18(1):e12871. doi: 10.1111/acel.12871. Epub 2018 Dec 17.

Female XX sex chromosomes increase survival and extend lifespan in aging mice.

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Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California.
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.


Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex-based differences in aging could lead to new pathways to counter age-induced decline in both sexes.


aging; four core genotype; life-span studies; mortality; mouse models; sex differences; sex hormones

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