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Inflamm Res. 2019 Mar;68(3):215-221. doi: 10.1007/s00011-018-1206-z. Epub 2018 Dec 17.

miR-196a2 (rs11614913) polymorphism is associated with coronary artery disease, but not with in-stent coronary restenosis.

Author information

1
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Del. Tlalpan, 14080, Mexico City, Mexico.
2
Endocrine and Metabolic Diseases Research Unit, Hospital Juárez de Mexico, Mexico City, Mexico.
3
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
4
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
5
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Del. Tlalpan, 14080, Mexico City, Mexico. gvargas63@yahoo.com.

Abstract

OBJECTIVE:

The aim of the study was to evaluate the association of miRNA-146a G/C (rs2910164), and miRNA-196a2 C/T (rs11614913) polymorphisms with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent.

MATERIALS AND METHODS:

The polymorphisms were determined in 218 patients with CAD who underwent coronary artery stenting (66 with restenosis and 152 without restenosis) and 611 healthy controls using 5' exonuclease TaqMan assays.

RESULTS:

The distribution of both polymorphisms was similar in patients with and without restenosis. However, when the whole group of patients (with and without restenosis) was compared to healthy controls, under co-dominant, dominant and additive genetic models, the T allele of the miRNA-196a2 C/T (rs11614913) polymorphism was associated with increased risk of CAD (OR = 2.18, Pco-dom = 0.006, OR = 1.86, Pdom = 0.002, and OR = 1.52, Padd = 0.002, respectively). All models were adjusted for age, type 2 diabetes mellitus, dyslipidemia, hypertension and smoking habit. The "GT" haplotype was associated with increased risk of developing CAD (OR = 1.36, P = 0.046).

CONCLUSIONS:

Our data suggests that the T allele of the miRNA-196a2 C/T (rs11614913) polymorphism is associated with the risk of developing CAD, but no association with restenosis was observed.

KEYWORDS:

Coronary artery disease; Coronary stenting; MicroRNA; Polymorphism; Restenosis

PMID:
30560371
DOI:
10.1007/s00011-018-1206-z
[Indexed for MEDLINE]

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