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Am J Ophthalmol. 1988 Nov 15;106(5):575-8.

Corneal allograft rejection following immunization.

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Department of Ophthalmology, University of Kentucky, Lexington 40536-0084.


Five patients developed corneal allograft rejection after immunization. One patient, a 33-year-old woman, received a tetanus toxoid booster nine months after a corneal transplant for keratoconus. Within four days she developed a graft rejection that required a penetrating keratoplasty two years later. Six months later, after hepatitis B immunization, the patient reported decreased vision and the graft was cloudy, but visual acuity was 20/20. The other four patients developed graft rejection after influenza immunization. Two of these four graft rejection episodes were successfully treated with high-dose corticosteroid therapy; all episodes occurred within several weeks of influenza immunization. Patients should be prudently counseled regarding the possible risks of immunization to corneal allograft survival.

[Indexed for MEDLINE]

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