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Trends Endocrinol Metab. 2019 Feb;30(2):93-105. doi: 10.1016/j.tem.2018.11.004. Epub 2018 Dec 14.

The Role of Immature and Mature Adipocytes in Hair Cycling.

Author information

1
Scientific Department, Wellcomet GmbH, Karlsruhe, Germany.
2
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA.
3
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA. Electronic address: philipp.scherer@utsouthwestern.edu.

Abstract

Hair follicles (HFs) strongly interact with adipocytes within the dermal white adipose tissue (dWAT), suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by the proliferation and differentiation of adipocyte precursors, as well as by dedifferentiation of mature existing adipocytes. Spatially, long-range interactions between HFs and dWAT involve the exchange of extracellular vesicles which are differentially released by precursors, preadipocytes, and mature adipocytes. Different exogenous factors, including light irradiation, are likely to modify the release of adipocyte-derived exosomes in dWAT, which can lead to aberrations of the HF cycle. Consequently, dWAT should be considered as a potential target for the modulation of hair growth.

KEYWORDS:

dermal white adipose tissue; exosomal exchange; hair follicle cycle; immature adipocytes; mature adipocytes

PMID:
30558832
PMCID:
PMC6348020
[Available on 2020-02-01]
DOI:
10.1016/j.tem.2018.11.004

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