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Medicine (Baltimore). 2018 Dec;97(50):e13246. doi: 10.1097/MD.0000000000013246.

Weight reduction and cardiovascular benefits: Protocol for a systematic review and meta-analysis.

Author information

1
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
2
Cardiovascular diseases center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
3
School of Nursing, the Hong Kong Polytechnic University, Kowloon, Hong Kong.
4
Graduate school of Beijing University of Chinese Medicine, Beijing, China.
5
Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

Abstract

BACKGROUND:

There is widespread obesity paradox in cardiovascular diseases, the cardiovascular influence from weight management remains controversial. Moreover, previous publications indicating that different weight reduction extent might lead to various results. Thus, it is of importance to reassess the cardiovascular benefits of weight management strategies.

OBJECTIVES:

This review is designed to assess the association between weight loss and cardiovascular outcomes.

METHODS:

Clinical trials including randomized control trials, observational studies reported a weight change before and after weight interventions including lifestyle intervention, as well as pharmacotherapies were included. Three major databases will be searched to retrieve the appropriate studies. Dual selection and abstraction of data will be conducted by 2 authors independently. The population, intervention, comparator, outcomes, study characteristics framework will be used to extract all the necessary data from included studies. The risk of bias assessment will be conducted in duplicate based on the Cochrane risk of bias guideline for randomized controlled trials (RCTs) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement for observational studies respectively. The primary outcomes will be the cardiovascular mortality, and the secondary outcomes are all-cause mortality and new cardiovascular events. A meta-analysis will be considered if there is sufficient homogeneity among selected studies. Follow the criteria of Grading of Recommendations, Assessment, Development and Evaluation (GRADE), the quality of the cumulative evidence will be evaluated.

RESULTS AND CONCLUSIONS:

The results of this systematic review could provide reliable and concrete evidence for weight loss and its cardiovascular benefits.Prospero registration number: CRD42018108582.

PMID:
30557969
PMCID:
PMC6319988
DOI:
10.1097/MD.0000000000013246
[Indexed for MEDLINE]
Free PMC Article

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