Format

Send to

Choose Destination
PLoS One. 2018 Dec 17;13(12):e0208905. doi: 10.1371/journal.pone.0208905. eCollection 2018.

Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis.

Author information

1
Center for Research and Development, Angeles University Foundation, Angeles City, Philippines.
2
Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City, Philippines.
3
Graduate School, University of Santo Tomas, Manila City, Philippines.
4
Institute of Clinical Laboratory Sciences, Silliman University, Dumaguete, Philippines.
5
Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila City, Philippines.
6
Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment and Climate Change, Toronto, Ontario, Canada.
7
Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila City, Philippines.

Abstract

BACKGROUND:

Managing nephropathy associated with diabetes mellitus warrant investigation of relevant biomarkers in predicting this condition. Adiponectin (ADP) may hold promise as a biomarker for diabetic nephropathy (DN). In this study, we examine associations of ADP with DN by meta-analyzing relevant literature. We also examined the predictive potential of ADP and estimate progression of DN.

METHODS:

Multi-database literature searches and serial omissions of articles yielded 13 studies for inclusion in the meta-analysis. We compared ADP levels between controls/ normoalbuminuria and cases with micro- and macroalbuminuria (MI and MA, respectively) as well as MI versus MA using standardized mean differences (SMD). Associations of ADP with DN were indicated with the P-value considered significant at ≤ 0.05. Subgrouping was based on diabetes type (1 and 2). Predictive potential of ADP was explored with AUC (area under the curve) derived from Receiver Operating Characteristic curve analysis.

RESULTS AND CONCLUSION:

At high P-values of <10-5, overall and subgroup outcomes indicated ADP associations with DN (up to SMD = 1.89-2.26, respectively). However, heterogeneity of the initial SMD effects (up to I2 = 99%) warranted examination of their sources which with the Galbraith plot method, either eliminated or reduced their heterogeneity, signifying combinability of the studies. This feature along with consistency of significant associations, robust outcomes and significant AUC values provide good evidence of the associative and predictive roles of ADP in DN.

PMID:
30557306
PMCID:
PMC6296550
DOI:
10.1371/journal.pone.0208905
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center