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Front Microbiol. 2018 Nov 30;9:2655. doi: 10.3389/fmicb.2018.02655. eCollection 2018.

Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites.

Author information

1
Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
2
Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
3
Department of Microbiology, The Ohio State University, Columbus, OH, United States.

Abstract

The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs are toxic and prolonged with poor patient compliance. In addition, emergence of drug-resistant parasites is increasing worldwide. Hence, there is a need for safer and better therapeutics for these infections. Host-directed therapy using drugs that target host pathways required for pathogen survival or its clearance is a promising approach for treating infections. This review will give a summary of the current status and advances of host-targeted therapies for treating NTDs caused by protozoa.

KEYWORDS:

Chagas disease; Human African Trypanosomiasis; host-directed therapy; leishmaniasis; treatment

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