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Biochem Biophys Res Commun. 2019 Jan 22;508(4):1182-1187. doi: 10.1016/j.bbrc.2018.12.073. Epub 2018 Dec 14.

Chronic social defeat stress-induced enhancement of T-type calcium channels increases burst-firing neurons in the ventral subiculum.

Author information

1
Department of Biology, Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
2
Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.
3
Department of Biology, Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea. Electronic address: kisoon_shin@khu.ac.kr.

Abstract

The ventral subiculum (vSub), a representative output structure of the hippocampus, serves as a main limbic region in mediating the brain's response to stress. There are three subtypes of subicular pyramidal neurons based on their firing patterns: regular-spiking (RS), weak-bursting (WB) and strong-bursting (SB) neurons, located differently along proximal-distal axis. Here, we found that chronic social defeat stress (CSDS) in mice increased the population of SB neurons but decreased RS neurons in the proximal vSub. Specific blockers of T-type calcium channels inhibited the burst firings with a concomitant reduction of afterdepolarization, suggesting that T-type calcium channels underlie the burst-spiking activity. Consistently, CSDS increased both T-type calcium currents and expression of Cav3.1 proteins, a subtype of T-type calcium channels, in the proximal vSub. Therefore, we conclude that CSDS-induced enhancement of Cav3.1 expression increased bursting neuronal population in the vSub, which may contribute to stress-related behaviors.

KEYWORDS:

Burst firing; Cav3.1; Social defeat stress; T-type calcium channels; Ventral subiculum

PMID:
30554654
DOI:
10.1016/j.bbrc.2018.12.073

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