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Can J Neurol Sci. 2018 Dec 17:1-7. doi: 10.1017/cjn.2018.373. [Epub ahead of print]

Magnetoencephalographic Source Localization of the Eye Area of the Motor Homunculus.

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1Division of Neurology,Krembil Brain Institute,University Health Network, Toronto Western Hospital,University of Toronto,Toronto, Ontario,Canada.


A patient with intractable epilepsy, previous right frontal resection, and active vagus nerve stimulation (VNS) developed new onset quasi-continuous twitching around the left eye. Electroencephalography showed no correlate to the orbicularis oculi twitches apart from myographic potentials at the left supraorbital and anterior frontal electrodes. Magnetoencephalography was performed using spatiotemporal signal space separation to suppress magnetic artifacts associated with the VNS apparatus. Magnetoencephalographic source imaging performed on the data back-averaged from the left supraorbital myographic potentials revealed an intrasulcal cortical generator situated in the posterior wall of the right precentral gyrus representing the eye area of the motor homunculus.


Electroencephalography (EEG); Epilepsia partialis continua (EPC); MEG source imaging (MSI); Orbicularis oculi; Spatiotemporal signal space separation (tSSS); Vagus nerve stimulation (VNS)


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