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Carbohydr Polym. 2019 Feb 15;206:435-445. doi: 10.1016/j.carbpol.2018.10.068. Epub 2018 Oct 29.

Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment.

Author information

1
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address: cylsy@163.com.
2
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
3
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, PR China; Research School of Engineering, College of Engineering and Computer Science, The Australian National University, Canberra, ACT, 2601, Australia.
4
Department of Clinical Laboratory, People's Hospital of Pudong New District, Shanghai, 201200, PR China.
5
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, PR China. Electronic address: jinyg@sina.com.
6
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, PR China.
7
Agriculture Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, 524001, PR China.
8
School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang, 524001, PR China.

Abstract

Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. With the aid of microwave drying, hydroxylated lecithin complexed iodine/carboxymethly chitosan/sodium alginate (HLI/CMCS/SA) composite membranes with homogeneously distributions of HLI, high contents of activated iodine, good mechanical and swelling properties, proper water vapor permeability, pH controllable iodine release and excellent antibacterial properties were prepared. The composite membranes exhibited high repairing efficiencies for the infection of a rat model of the seawater immersed wound infection of deep partial-thickness burns. This novel antibacterial composite membrane can be potentially used as a high performance wound dressing for treating and repairing open trauma infections.

KEYWORDS:

Carboxymethyl chitosan; Hydroxylated lecithin; Iodine; Membrane; Sodium alginate; Wound dressing

PMID:
30553343
DOI:
10.1016/j.carbpol.2018.10.068
[Indexed for MEDLINE]

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