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Head Neck. 2019 Jan;41(1):92-102. doi: 10.1002/hed.25383. Epub 2018 Dec 15.

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.

Lee YA1, Li S1, Chen Y1, Li Q2, Chen CJ3,4, Hsu WL3, Lou PJ5, Zhu C6, Pan J7, Shen H8, Ma H8, Cai L9, He B9, Wang Y10,11, Zhou X11,12, Ji Q10,11, Zhou B13, Wu W13, Ma J14, Boffetta P15, Zhang ZF16, Dai M17, Hashibe M1.

Author information

1
Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
2
Departments of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
3
Genomics Research Center, Academia Sinica, Taipei, Taiwan.
4
Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
5
Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
6
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Sichuan, China.
7
Department of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan, China.
8
Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
9
Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University, Fujian, China.
10
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
11
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
12
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
13
Department of Epidemiology, School of Public Health, China Medical University, Liaoning, China.
14
Department of Head & Neck Oncology, Henan Cancer Hospital, Henan, China.
15
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York.
16
Department of Epidemiology, and Center for Environmental Genomics, Fielding School of Public Health, University of California, Los Angeles, California.
17
National Office of Cancer Prevention and Control Cancer Institute and Hospital, and Chinese Academy of Medical Sciences, Beijing, China.

Abstract

BACKGROUND:

The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.

METHODS:

A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression.

RESULTS:

Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer.

CONCLUSIONS:

Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S.

POPULATIONS:

KEYWORDS:

alcohol drinking; attributable fraction, head and neck cancer risk; betel quid chewing; tobacco smoking

PMID:
30552826
DOI:
10.1002/hed.25383

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