Format

Send to

Choose Destination
Diabetes Care. 2019 Feb;42(2):327-330. doi: 10.2337/dc18-1302. Epub 2018 Dec 14.

Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes.

Author information

1
Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
2
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
3
Department of Radiology, Karolinska University Hospital, and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
4
Joslin Diabetes Center, Harvard Medical School, Boston, MA.
5
Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
6
Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.
7
Department of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
8
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
9
Department of Radiology, Helsinki University Hospital, Helsinki, Finland.

Abstract

OBJECTIVE:

To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD.

RESEARCH DESIGN AND METHODS:

This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD.

RESULTS:

Cerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% (P = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% (P = 0.008), white matter hyperintensities 17% vs. 6.7% (P = 0.182), and lacunes 2.1% vs. 0% (P = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00-1.05], P = 0.035).

CONCLUSIONS:

Cerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.

PMID:
30552131
DOI:
10.2337/dc18-1302
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center