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Rev Infect Dis. 1988 Jul-Aug;10 Suppl 2:S274-6.

Molecular Koch's postulates applied to microbial pathogenicity.

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Department of Microbiology, and Immunology, Stanford University, California 94305.


Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in the pathogenesis of infection and disease.

[Indexed for MEDLINE]

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