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Curr Opin Insect Sci. 2018 Oct;29:12-20. doi: 10.1016/j.cois.2018.05.016. Epub 2018 May 26.

G protein-coupled receptors in arthropod vectors: omics and pharmacological approaches to elucidate ligand-receptor interactions and novel organismal functions.

Author information

1
Department of Entomology, Texas A&M University (TAMU), College Station, TX 77843-2475, United States. Electronic address: p-pietrantonio@tamu.edu.
2
Department of Entomology, TAMU, College Station, TX 77843-2475, United States.
3
Southern Plains Agricultural Research Center, USDA-ARS, College Station, TX 77845, United States.
4
Department of Electrical and Computer Engineering, TAMU, College Station, TX 77843-3128, United States.

Abstract

Regulation of many physiological processes in animals, certainly those controlled by neuropeptide hormones, involves G protein-coupled receptors (GPCRs). Our work focusing on endocrine regulation of diuresis and water balance in mosquitoes and ticks started in 1997 with the kinin receptor, at the dawn of the omics era. After the genomic revolution, we began work on the endocrinology of reproduction in the red imported fire ant. We will use the template of this comparative work to summarize key points about GPCRs and signaling, and emphasize the most recent developments in the pharmacology of arthropod neuropeptide GPCRs. We will discuss omics' contributions to the advancement of this field, and its influence on peptidomimetic design while emphasizing work on blood feeding arthropods.

PMID:
30551818
PMCID:
PMC6296246
[Available on 2019-10-01]
DOI:
10.1016/j.cois.2018.05.016

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