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Biomed Pharmacother. 2019 Jan;109:1085-1099. doi: 10.1016/j.biopha.2018.10.130. Epub 2018 Nov 6.

In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature.

Author information

1
State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China; School of pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
2
State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China.
3
School of Pharmacology, Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan, 750004, China.
4
School of pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: cz@cpu.edu.cn.
5
State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: yy@cpu.edu.cn.

Abstract

Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Finally, we contemplate future development and application prospects of quercetin. Despite the wealth of in animal research results suggesting the anti-diabetic and its complications potential of quercetin, its efficacy in diabetic human subjects is yet to be explored. The problem may become an important direction in the future research.

KEYWORDS:

Diabetes; Diabetic complications; In vitro and in vivo evidence; Quercetin

PMID:
30551359
DOI:
10.1016/j.biopha.2018.10.130
[Indexed for MEDLINE]
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