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Medwave. 2018 Dec 14;18(8):e7376. doi: 10.5867/medwave.2018.08.7375.

Combined therapy with levothyroxine and liothyronine for hypothyroidism.

[Article in English, Spanish; Abstract available in Spanish from the publisher]

Author information

1
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
2
Proyecto Epistemonikos, Santiago, Chile; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: jdomingu@uc.cl. Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Abstract

in English, Spanish

INTRODUCTION:

The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine and levothyroxine would provide a greater benefit.

METHODS:

We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.

RESULTS AND CONCLUSIONS:

We identified three systematic reviews including twelve primary studies overall, all of which were randomized trials. We concluded that the addition of liothyronine to the treatment of hypothyroidism has minimal or no effect on fatigue and quality of life. It probably does not improve mood, pain or function cognitive, and it would not reduce body weight.

KEYWORDS:

Epistemonikos; GRADE; addition of LT3; combination therapy; hypothyroidism

PMID:
30550536
DOI:
10.5867/medwave.2018.08.7375
[Indexed for MEDLINE]

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