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Curr Opin Clin Nutr Metab Care. 2018 Dec 13. doi: 10.1097/MCO.0000000000000538. [Epub ahead of print]

Is diet management helpful in familial hypercholesterolemia?

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1
FH Foundation, Pasadena, California, USA.

Abstract

PURPOSE OF REVIEW:

Familial hypercholesterolemia is a genetic condition where low-density lipoprotein (LDL) receptor defects cause severe elevations of LDL cholesterol. As significant LDL-lowering effects are needed, medication is considered the cornerstone of therapy, and dietary therapy has received less emphasis. This review will re-visit older studies of diet intervention and new insights from genetic and mechanistic studies to determine the value of diet management for familial hypercholesterolemia patients.

RECENT FINDINGS:

Saturated fat reduction improves cardiovascular outcomes, particularly in those with genetic predisposition to risk. Secular trends in saturated fat intake may have improved familial hypercholesterolemia outcomes. Dietary mechanisms of LDL cholesterol-lowering complement pharmacologic approaches.

SUMMARY:

Diet treatment adds incremental health benefit to pharmacologic treatment in familial hypercholesterolemia.

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