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Ann Neurol. 2019 Feb;85(2):259-271. doi: 10.1002/ana.25392. Epub 2019 Jan 7.

Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.

Author information

1
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania.
2
Digital Neuropathology Laboratory, Perelman School of Medicine at the University of Pennsylvania.
3
Frontotemporal Dementia Center, Perelman School of Medicine at the University of Pennsylvania.
4
Parkinson's Disease and Movement Disorders Center, Perelman School of Medicine at the University of Pennsylvania.
5
Alzheimer's Disease Center, Perelman School of Medicine at the University of Pennsylvania.
6
Department of Biostatistics, Epidemiology and Informatics Perelman School of Medicine at the University of Pennsylvania.
7
Michael J. Crescenz VA Medical Center, Parkinson's Disease Research, Education, and Clinical Center, Philadelphia, PA, USA 19104.
8
Center for Cognitive Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
9
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania.
10
Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania.

Abstract

OBJECTIVE:

To use digital histology in a large autopsy cohort of Lewy body disorder (LBD) patients with dementia to test the hypotheses that co-occurring Alzheimer disease (AD) pathology impacts the anatomic distribution of α-synuclein (SYN) pathology and that co-occurring neocortical tau pathology in LBDs associates with worse cognitive performance and occurs in a pattern differing from AD.

METHODS:

Fifty-five autopsy-confirmed LBD (Parkinson disease with dementia, n = 36; dementia with Lewy bodies, n = 19) patients and 25 AD patients were studied. LBD patients were categorized as having moderate/severe AD copathology (SYN + AD = 20) or little/no AD copathology (SYN-AD = 35). Digital measures of tau, β-amyloid (Aβ), and SYN histopathology in neocortical and subcortical/limbic regions were compared between groups and related to antemortem cognitive testing.

RESULTS:

SYN burden was higher in SYN + AD than SYN-AD in each neocortical region (F1, 54 = 5.6-6.0, p < 0.02) but was equivalent in entorhinal cortex and putamen (F1, 43-49 = 0.7-1.7, p > 0.2). SYN + AD performed worse than SYN-AD on a temporal lobe-mediated naming task (t27 = 2.1, p = 0.04). Antemortem cognitive test scores inversely correlated with tau burden (r = -0.39 to -0.68, p < 0.05). AD had higher tau than SYN + AD in all regions (F1, 43 = 12.8-97.2, p < 0.001); however, SYN + AD had a greater proportion of tau in the temporal neocortex than AD (t41 = 2.0, p < 0.05), whereas AD had a greater proportion of tau in the frontal neocortex than SYN + AD (t41 = 3.3, p < 0.002). SYN + AD had similar severity and distribution of neocortical Aβ compared to AD (F1, 40-43 = 1.6-2.0, p > 0.1).

INTERPRETATION:

LBD patients with AD copathology harbor greater neocortical SYN pathology. Regional tau pathology relates to cognitive performance in LBD dementia, and its distribution may diverge from pure AD. Tau copathology contributes uniquely to the heterogeneity of cognitive impairment in LBD. Ann Neurol 2018; 1-13 ANN NEUROL 2019;85:259-271.

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