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Breast J. 2019 Jan;25(1):75-79. doi: 10.1111/tbj.13153. Epub 2018 Dec 12.

Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases.

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Department of Radiation Oncology, University of Florida, Gainesville, Florida.
Department of Radiation Oncology, University of Miami, Miami, Florida.
Department of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, Florida.


This article presents current best knowledge to assess the projected outcomes benefit of adding multi-modality surveillance imaging to standard follow-up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early-stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease-free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high-risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol.


body imaging; breast cancer; metastases

[Indexed for MEDLINE]

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