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Breast J. 2019 Jan;25(1):75-79. doi: 10.1111/tbj.13153. Epub 2018 Dec 12.

Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases.

Author information

1
Department of Radiation Oncology, University of Florida, Gainesville, Florida.
2
Department of Radiation Oncology, University of Miami, Miami, Florida.
3
Department of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, Florida.

Abstract

This article presents current best knowledge to assess the projected outcomes benefit of adding multi-modality surveillance imaging to standard follow-up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early-stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease-free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high-risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol.

KEYWORDS:

body imaging; breast cancer; metastases

PMID:
30548515
DOI:
10.1111/tbj.13153
[Indexed for MEDLINE]

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