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Transbound Emerg Dis. 2018 Dec 11. doi: 10.1111/tbed.13099. [Epub ahead of print]

Diversified sources for human infections by Salmonella enterica serovar newport.

Author information

1
CATG Microbiology & Food Safety Laboratory, Institute of Preventive Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.
2
Zhejiang Province Center for Disease Control and Prevention, Hangzhou, China.
3
Dongyang People's Hospital, Dongyang, China.
4
Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
5
Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou, China.
6
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
7
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.

Abstract

Salmonella enterica Newport (S. Newport), with phylogenetic diversity feature, contributes to significant public health concerns. Our previous study suggested that S. Newport from multiple animal-borne routes, with distinct antibiotic resistant pattern, might transmit to human. However, their genetic information was lacking. As a complement to the earlier finding, we investigate the relationship between each other among the hosts, sources, genotype and antibiotic resistance in S. Newport. We used the multilocus sequence typing (MLST) in conjunction with minimum inhibitory concentration of 16 antibiotics of globally sampled 1842 S. Newport strains, including 282 newly contributed Chinese strains, to evaluate this association. Our analysis reveals that sequence types (STs) are significantly associated with different host sources, including livestock (ST45), birds (ST5), contaminated water and soil (ST118), reptiles (ST46) and seafood (ST31). Importantly, ST45 contained most of (344/553) the multi-drug resistance (MDR) strains, which were believed to be responsible for human MDR bacterial infections. Chinese isolates were detected to form two unique lineages of avian (ST808 group) and freshwater animal (ST2364 group) origin. Taken together, genotyping information of S. Newport could serve to improve Salmonella source-originated diagnostics and guide better selection of antibiotic therapy against Salmonella infections.

KEYWORDS:

Salmonella Newport; antibiotic resistance; bovine; plant; sequence type; sources

PMID:
30548172
DOI:
10.1111/tbed.13099

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