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Phytother Res. 2019 Mar;33(3):651-659. doi: 10.1002/ptr.6254. Epub 2018 Dec 10.

Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial.

Author information

1
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
2
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
4
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
5
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
6
Iranian Diabetes Association, Tehran, Iran.

Abstract

Melissa officinalis is a plenteous source of antioxidant flavonols and flavonoids that contain health-promoting and antidiabetic properties, so this study was undertaken to provide the first assessment of the antidiabetic properties of hydroalcoholic extract of M. officinalis in type 2 diabetic patients. We did a randomized, placebo-controlled trial which included 62 patients, receiving either M. officinalis capsules (700 mg/d; n = 31) or the placebo (n = 31) twice daily for 12 weeks. There were significant differences in serum FBS (P = 0.007), HbA1c (P = 0.002), β-cell activity (P = 0.05), TG (P = 0.04), HDL-c (P = 0.05), hs-CRP (P = 0.001), and systolic blood pressure (P = 0.04) between the two groups at the end of the study; but total cholesterol, LDL-c, insulin, and HOMA-IR showed no significant changes between the groups. In M. officinalis group, there was a significant change in HDL-c (P = 0.009) and QUICKI (P = 0.005) compared with baseline values. No adverse effects were observed. It seems that M. officinalis is safe and effective in improvement of lipid profile, glycemic control, and reduction of inflammation.

KEYWORDS:

Melissa officinalis; antidiabetic; flavonoid; hypoglycemic; lemon balm

PMID:
30548118
DOI:
10.1002/ptr.6254
[Indexed for MEDLINE]

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