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Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):728-30.

[Pharmacokinetics of trometamol-fosfomycin in patients with renal insufficiency].

[Article in French]

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Service de Néphrologie, UER de Rouen, Hôpital de Bois-Guillaume.


Trometamol fosfomycin is a new form of fosfomycin used orally. We have studied pharmacokinetics of this antibiotic in 23 uraemic patients with various degrees of renal insufficiency. The control group was 5 young adult males with a creatinine clearance of 127 +/- 20 ml/mn. All subjects received a single oral dose of 25 mg/kg trometamol fosfomycin. Serum and urine concentrations of fosfomycin were assayed by a microbiological method. Cmax, tmax, AUC were significantly higher in uraemic patients than in normal subjects. t 1/2 beta were prolonged in uraemic patients. Thus it is necessary to modify usual dose regimen when creatinine clearance is below 50 ml/mn.

[Indexed for MEDLINE]

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