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BMB Rep. 2019 Feb;52(2):139-144.

SETDB1 regulates SMAD7 expression for breast cancer metastasis.

Author information

1
Korea Research Institute of Bioscience and Biotechnology, Korea University of Science and Technology, Daejeon 34141, Korea.
2
Korea Institute of Toxicology (KIT), Daejeon 34114, Korea.
3
Korea Research Institute of Bioscience and Biotechnology, and Department of Functional Genomics, Korea University of Science and Technology, Daejeon 34141, Korea.

Abstract

Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. In Gene Ontology (GO) analysis, cell migration-related GO terms were enriched, and we confirmed down-regulation of cell migration/invasion and alteration of EMT /MET markers after knockdown of SETDB1. Moreover, gene network analysis showed that SMAD7 expression is regulated by SETDB1 levels, indicating that up-regulation of SMAD7 by SETDB1 knockdown inhibited BRC metastasis. Therefore, development of SETDB1 inhibitors and functional studies may help develop more effective clinical guidelines for BRC treatment. [BMB Reports 2019; 52(2): 139-144].

PMID:
30545440
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