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Materials (Basel). 2018 Dec 12;11(12). pii: E2529. doi: 10.3390/ma11122529.

Freeform Perfusable Microfluidics Embedded in Hydrogel Matrices.

Author information

1
IRNAS-Institute for development of advanced applied systems, Valvasorjeva 42, 2000 Maribor, Slovenia. gabi.stumberger@gmail.com.
2
IRNAS-Institute for development of advanced applied systems, Valvasorjeva 42, 2000 Maribor, Slovenia. bostjan@irnas.eu.

Abstract

We report a modification of the freeform reversible embedding of suspended hydrogels (FRESH) 3D printing method for the fabrication of freeform perfusable microfluidics inside a hydrogel matrix. Xanthan gum is deposited into a CaCl₂ infused gelatine slurry to form filaments, which are consequently rinsed to produce hollow channels. This provides a simple method for rapid prototyping of microfluidic devices based on biopolymers and potentially a new approach to the construction of vascular grafts for tissue engineering.

KEYWORDS:

FRESH; bioprinting; freeform; gelatine; hydrogel; microfluidics; vascularization

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