Format

Send to

Choose Destination
Medicine (Baltimore). 2018 Dec;97(49):e13243. doi: 10.1097/MD.0000000000013243.

Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report.

Author information

1
Institute for Applied Epistemology and Medical Methodology (IFAEMM) at the University of Witten/Herdecke, Freiburg i. Brsg.
2
Community practice for general medicine, Radebeul.
3
University Hospital Carl Gustav Carus.
4
Institute for pathology, University Hospital Carl Gustav Carus, TU Dresden, Dresden.
5
Department of Surgery, University hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg.
6
Department of Internal Medicine-Gastroenterology, Filderklinik, Filderstadt.
7
Department of Internal Medicine, Klinikum Niederlausitz, Senftenberg.
8
Institute for Applied Epistemology and Medical Methodology (IFAEMM) at the University of Witten/Herdecke, Freiburg i. Brsg., Germany.

Abstract

RATIONALE:

Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)-widely used as an adjunct to cancer treatment-have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically significant survival benefit has been demonstrated for VAE in advanced pancreatic cancer.

PATIENT CONCERNS AND DIAGNOSIS:

A 28-year old patient presented with painless jaundice and was subsequently diagnosed as pancreatic adenocarcinoma with liver metastases.

INTERVENTIONS:

He was treated with FOLFIRINOX/Mitomycin, hyperthermia and fever-inducing VAE.

OUTCOMES:

Subsequently, the liver metastases regressed. Surgical intervention involved successful R0-resection of the primary tumor, as well as an atypical liver resection. A relapse was again treated with FOLFIRINOX/Mitomycin and hyperthermia. As of publication of this report, 49 months after initial diagnosis, the patient exhibits good condition, and is unrestricted in quality of life (till publication).

LESSONS:

This case demonstrates the favorable outcome of a patient with metastatic pancreatic cancer following treatment with chemotherapy, integrative medicine, and surgical excision. As other positive outcomes in pancreatic cancer patients are related to inflammatory events, we presume the immunologic effects of VAE to have contributed to the favorable outcome here. Based on this case, and the other positive results of VAE use in pancreatic cancer, further investigations seem highly worthwhile.

PMID:
30544385
PMCID:
PMC6310555
DOI:
10.1097/MD.0000000000013243
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wolters Kluwer Icon for PubMed Central
Loading ...
Support Center