Format

Send to

Choose Destination
J Colloid Interface Sci. 2019 Mar 7;538:530-540. doi: 10.1016/j.jcis.2018.12.012. Epub 2018 Dec 4.

A remarkable thermosensitive hydrogel cross-linked by two inorganic nanoparticles with opposite charges.

Author information

1
College of Chemistry and Material Science, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, PR China.
2
College of Chemistry and Material Science, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, PR China; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand.
3
Department of Pediatric Orthopedics, Tai'an Central Hospital, Tai'an, Shandong 271000, PR China.
4
College of Chemistry and Material Science, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, PR China. Electronic address: fangll@sdau.edu.cn.

Abstract

Herein, we report the successful synthesis of a series of poly (N-isopropylacrylamide) (PNIPA)/layered double hydroxides (LDHs)/nano-hydroxyapatite (nano-HA) hydrogels via in-situ radical polymerization. The internal morphology, thermo sensitivity, rheological properties, swelling behavior and hemocompatibility of the PNIPA/LDHs/HA composite hydrogels were systematically investigated. Results show that the hydrogels had a reversible sol-gel transformation around 33 °C. Interactions between the positively charged LDHs and negatively charged nano-HA particles created a highly porous hydrogel network. The composite hydrogels exhibited excellent hemocompatibility, incredible mechanical toughness and reversible swelling/deswelling behavior. To our knowledge, this is the first reported study to use two types of inorganic nanoparticle with opposing charges as hydrogel crosslinking agents. Based on its properties, we expect this hydrogel has broad applications potential in tissue engineering, drug delivery and biosensor development.

KEYWORDS:

Hemocompatibility; Layered double hydroxides; N-isopropylacrylamide; Nano-hydroxyapatite; Rheological

PMID:
30544070
DOI:
10.1016/j.jcis.2018.12.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center