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Pediatr Infect Dis J. 2019 May;38(5):525-527. doi: 10.1097/INF.0000000000002168.

Predictors of Poor Outcomes Among Infants With Respiratory Syncytial Virus-associated Acute Lower Respiratory Infection in Botswana.

Author information

1
From the Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham, North Carolina.
2
The Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
3
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
4
Global Health Center.
5
Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
6
Botswana-UPenn Partnership, Gaborone, Botswana.
7
University of Botswana School of Medicine, Gaborone, Botswana.
8
Division of Hospital Medicine.
9
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
10
Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina.

Abstract

Among children 1-23 months of age with respiratory syncytial virus-associated acute lower respiratory infection in Botswana, young age (<6 months), household use of wood as a cooking fuel, moderate or severe malnutrition and oxygen saturation <90% on room air were independent predictors of clinical nonresponse at 48 hours. Among HIV-uninfected infants less than six months of age, HIV exposure was associated with a higher risk of in-hospital mortality.

PMID:
30543564
PMCID:
PMC6465100
[Available on 2020-05-01]
DOI:
10.1097/INF.0000000000002168

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