Format

Send to

Choose Destination
Obes Surg. 2019 Mar;29(3):869-877. doi: 10.1007/s11695-018-3611-3.

Changes in Sex Hormones After Laparoscopic Sleeve Gastrectomy in Chinese Obese Men: a 12-Month Follow-Up.

Zhu C1,2, Zhang Y3, Zhang L4, Gao J1,2, Mei F1,2, Zhu B1,2, Lu L5, Zhou D5, Qu S6,7.

Author information

1
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301 Middle Yanchang Road, Shanghai, 200072, China.
2
National Metabolic Management Center, Shanghai, 200072, China.
3
Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China.
4
Department of Endocrinology, Changzhou Cancer Hospital, Soochow University, Changzhou, 213032, Jiangsu, China.
5
Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
6
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301 Middle Yanchang Road, Shanghai, 200072, China. qushencn@hotmail.com.
7
National Metabolic Management Center, Shanghai, 200072, China. qushencn@hotmail.com.

Abstract

BACKGROUND:

To examine changes in sex hormones after laparoscopic sleeve gastrectomy (LSG) in Chinese obese male patients and their correlation with metabolic parameters including serum uric acid (SUA) METHODS: A total of 56 obese men with body mass index (BMI) 41.9 ± 5.8 kg/m2 undergoing LSG were selected. Thirty-one healthy men with normal BMI were included as controls. Levels of total testosterone (TT), estradiol (E2), sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), SUA, and other metabolic indices were compared pre- and 12 months post-LSG. Calculated free testosterone (cFT) was calculated from TT and SHBG using an empirical equation.

RESULTS:

At baseline, low TT and hyperuricemia (HUA) were common in obese men. Twelve months after LSG, statistically significant reduction in weight, BMI, and glucolipid metabolism indices was noted. SUA levels declined remarkably from 474.9 ± 94.6 to 338.8 ± 81.9 μmol/L and the percentage of HUA decreased from 76.8 to 54.1% (all P < 0.001). Additionally, significant increases in TT, SHBG, and cFT as well as a decrease in percentage of low TT were observed after LSG (all P < 0.05), while E2, FSH, and LH did not change significantly. Moreover, changes in TT levels were more pronounced than those of other sex hormones. After age and BMI were adjusted, increased TT levels were correlated significantly with decreased SUA (β = - 1.077, P < 0.05), BMI (β = - 0.712, P < 0.001), and HOMA-IR (β = - 0.652, P < 0.05), as well as increased SHBG (β = 0.759, P < 0.001).

CONCLUSIONS:

LSG promotes a significant increase in TT levels in Chinese obese men, which may be mediated by substantial weight loss, SUA reduction, and improved insulin resistance (IR).

KEYWORDS:

Laparoscopic sleeve gastrectomy; Obesity; Sex hormone-binding globulin; Total testosterone; Uric acid

PMID:
30542824
DOI:
10.1007/s11695-018-3611-3

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center