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J Exp Med. 2019 Jan 7;216(1):71-83. doi: 10.1084/jem.20180200. Epub 2018 Dec 12.

Astrocytes and microglia: Models and tools.

Author information

1
Department of Neurobiology, Stanford University, Stanford, CA kguttenp@stanford.edu.
2
Neuroscience Institute, NYU Langone Medical Center, New York, NY.
3
Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY.
4
Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, Australia.

Abstract

Glial cells serve as fundamental regulators of the central nervous system in development, homeostasis, and disease. Discoveries into the function of these cells have fueled excitement in glial research, with enthusiastic researchers addressing fundamental questions about glial biology and producing new scientific tools for the community. Here, we outline the pros and cons of in vivo and in vitro techniques to study astrocytes and microglia with the goal of helping researchers quickly identify the best approach for a given research question in the context of glial biology. It is truly a great time to be a glial biologist.

PMID:
30541903
PMCID:
PMC6314517
[Available on 2019-07-07]
DOI:
10.1084/jem.20180200

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