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Sci Transl Med. 2018 Dec 12;10(471). pii: eaar4321. doi: 10.1126/scitranslmed.aar4321.

Comment on "ALK is a therapeutic target for lethal sepsis".

Author information

1
Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115 USA.
2
Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino 10126 Italy.
3
Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115 USA. roberto.chiarle@childrens.harvard.edu.

Abstract

Physiologically relevant ALK (anaplastic lymphoma kinase) expression was not detected in human and mouse monocytes and macrophages, suggesting that the effects of bioactive compounds on stimulator of interferon genes (STING) activation may not depend on ALK.

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PMID:
30541790
PMCID:
PMC6459396
DOI:
10.1126/scitranslmed.aar4321
[Indexed for MEDLINE]
Free PMC Article

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