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BMC Med. 2018 Dec 13;16(1):232. doi: 10.1186/s12916-018-1225-1.

Insulin translates unfavourable lifestyle into obesity.

Author information

1
Faculty of Medicine, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
2
West German Centre of Diabetes and Health, Duesseldorf Catholic Hospital Group, Hohensandweg 37, 40591, Duesseldorf, Germany.
3
Department of Endocrinology and Nephrology, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
4
Biomedical and Scientific Consulting, 55130, Mainz, Germany.
5
West German Centre of Diabetes and Health, Duesseldorf Catholic Hospital Group, Hohensandweg 37, 40591, Duesseldorf, Germany. kerstin.kempf@wdgz.de.

Abstract

Lifestyle factors conferring increased diabetes risk are associated with elevated basal insulin levels (hyperinsulinaemia). The latter predicts later obesity in children and adolescents.A causal role of hyperinsulinaemia for adipose tissue growth is probable because pharmacological reduction of insulin secretion lowers body weight in people who are obese. Genetic inactivation of insulin gene alleles in mice also lowers their systemic insulin levels and prevents or ameliorates high-fat diet-induced obesity. Hyperinsulinaemia causes weight gain because of a physiological property of insulin. Insulin levels that are on the high side of normal, or which are slightly elevated, are sufficient to suppress lipolysis and promote lipogenesis in adipocytes. The effect of insulin on glucose transport or hepatic glucose production requires six or two times higher hormone levels, respectively.It seems justified to suggest a lifestyle that avoids high insulin levels in order to limit anabolic fat tissue activity.

KEYWORDS:

Hyperinsulinaemia; Insulin; Lifestyle; Lipolysis; Obesity; Type 2 diabetes mellitus

PMID:
30541568
PMCID:
PMC6292073
DOI:
10.1186/s12916-018-1225-1
[Indexed for MEDLINE]
Free PMC Article

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