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PLoS One. 2018 Dec 12;13(12):e0207936. doi: 10.1371/journal.pone.0207936. eCollection 2018.

Gene expression is implicated in the ability of pikas to occupy Himalayan elevational gradient.

Author information

1
Department of Biology, Stanford University, Stanford, California, United States of America.
2
Woods Institute for the Environment, Stanford University, Stanford, California, United States of America.
3
National Centre for Biological Sciences, TIFR, Bangalore, India.
4
Program for Conservation Genomics, Stanford University, Stanford, California, United States of America.
5
Center for Innovation in Global Health, Stanford University, Stanford, California, United States of America.

Abstract

Species are shifting their ranges due to climate change, many moving to cooler and higher locations. However, with elevation increase comes oxygen decline, potentially limiting a species' ability to track its environment depending on what mechanisms it has available to compensate for hypoxic stress. Pikas (Family Ochotonidae), cold-specialist small mammal species, are already undergoing elevational range shifts. We collected RNA samples from one population of Ochotona roylei in the western Himalaya at three sites- 3,600, 4,000, and 5,000 meters-and found no evidence of significant population genetic structure nor positive selection among sites. However, out of over 10,000 expressed transcripts, 26 were significantly upregulated at the 5,000 m site and were significantly enriched for pathways consistent with physiological compensation for limited oxygen. These results suggest that differences in gene expression may play a key role in enabling hypoxia tolerance on this local scale, indicating elevational flexibility that may facilitate successful range shifts in response to climate change.

Conflict of interest statement

The authors have declared that no competing interests exist.

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