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Physiology (Bethesda). 2019 Jan 1;34(1):5-13. doi: 10.1152/physiol.00021.2018.

Scaling of Motor Output, From Mouse to Humans.

Author information

1
Centre de Neurophysique, Physiologie, et Pathologie, UMR 8119 CNRS/Université Paris Descartes , Paris , France.
2
Physiology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
3
Physical Therapy and Human Movement Sciences, Physiology, Northwestern University Feinberg School of Medicine , Chicago, Illinois.
4
Physiology, Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine , Chicago, Illinois.

Abstract

Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.

PMID:
30540233
DOI:
10.1152/physiol.00021.2018

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