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Arq Gastroenterol. 2018 Jul-Sep;55(3):264-266. doi: 10.1590/S0004-2803.201800000-67.

ACUTE GASTROENTERITIS ASSOCIATED WITH NOROVIRUS GII.4 VARIANTS.

Author information

1
Universidade Federal da Bahia (UFBA), Instituto de Ciências da Saúde, Laboratório de Virologia, Salvador, BA, Brasil.
2
Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Santo Antônio de Jesus, BA, Brasil.
3
Universidade Estadual do Sudoeste da Bahia (UESB), Departamento de Ciências Biológicas, Jequié, BA, Brasil.
4
Universidade Federal da Bahia (UFBA), Instituto de Biologia, Laboratório de Genética de Populações e Evolução Molecular, Salvador, BA, Brasil.

Abstract

BACKGROUND:

Norovirus (NoV) is an important etiologic agent of acute gastroenteritis and infects individuals of all ages, especially children in Brazil and worldwide. NoV GII.4 was the most prevalent genotype worldwide because of your extensive genetic diversity. In Brazil, especially in the Northeast, few studies have been developed for identify and molecularly characterize NoV.

OBJECTIVE:

The present study aimed to detect and describe the molecular epidemiology of NoV associated with acute gastroenteritis.

METHODS:

The viral RNA extracted from stool samples were subjected to Nested RT-PCR and the genotypes were determined by nucleotide sequences analysis. In total, 278 stool samples assisted at Aliança Hospital in the city of Salvador, with acute gastroenteritis were examined, between March 2009 and July 2012.

RESULTS:

A high NoV rate (54.2%) was identified in children under 5 years of age. We detected the circulation of different NoV GII.4 variants in Salvador, during the study period as Den Haag 2006b, New Orleans 2009 and Sydney 2012.

CONCLUSION:

These findings reinforce the need to study the molecular epidemiology of NoV infections in acute gastroenteritis.

PMID:
30540089
DOI:
10.1590/S0004-2803.201800000-67
[Indexed for MEDLINE]
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