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Cytokine. 2019 Jan;113:400-404. doi: 10.1016/j.cyto.2018.10.012. Epub 2018 Oct 24.

Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment.

Author information

1
Department of Medicine, University Hospital Leipzig, 04103 Leipzig, Germany; IFB AdiposityDiseases, University of Leipzig, 04103 Leipzig, Germany.
2
Department of Medicine, University Hospital Leipzig, 04103 Leipzig, Germany.
3
Max-Planck-Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
4
Max-Planck-Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Day Clinic of Cognitive Neurology, University of Leipzig, 04103 Leipzig, Germany.
5
Department of Medicine, University Hospital Leipzig, 04103 Leipzig, Germany; IFB AdiposityDiseases, University of Leipzig, 04103 Leipzig, Germany; Institute of Nutritional Science, Justus-Liebig-University, 35390 Giessen, Germany.
6
Department of Medicine, University Hospital Leipzig, 04103 Leipzig, Germany. Electronic address: haiko.schloegl@medizin.uni-leipzig.de.

Abstract

AIM:

Metreleptin treatment in lipodystrophy patients improves eating behavior with increased satiety and reduced hunger. However, no data are available whether effects are maintained beyond 52 weeks of treatment.

METHODS:

A prospective study with measurements at baseline and at >150 weeks of metreleptin treatment was performed. Five female lipodystrophy patients with indication for metreleptin were included. Behavioral aspects of hunger- and satiety regulation were assessed by validated eating behavior questionnaires and visual analog scales assessing hunger and satiety feelings before and after a standardized meal.

RESULTS:

Hunger rated on visual analog scales at 120 min after the meal significantly decreased from 46 ± 10 mm at baseline to 17 ± 6 mm at long-term assessment. Furthermore, satiety at 5 and 120 min after the meal significantly increased from baseline to long-term assessment (5 min: 70 ± 7 mm to 87 ± 3 mm; 120 min: 43 ± 10 mm to 79 ± 8 mm). On the Three Factor Eating Questionnaire, the mean value of factor 3 (hunger) significantly decreased from 9.2 ± 0.2 at baseline to 2.6 ± 1.5 at long-term assessment. In the Inventory of Eating Behavior and Weight Problems Questionnaire, mean values for scale 2 (strength and triggering of desire to eat) and scale 7 (cognitive restraint of eating) significantly decreased from baseline (31.6 ± 4.8 and 11.4 ± 2.2, respectively) to long-term assessment (14.0 ± 2.1 and 10.0 ± 1.9).

CONCLUSION:

First evidence is presented that long-term metreleptin treatment of >150 weeks has sustained effects on eating behavior with increased satiety, as well as reduced hunger and hunger-related measures.

KEYWORDS:

Eating behavior; Hunger regulation; Leptin; Lipodystrophy; Metreleptin

PMID:
30539782
DOI:
10.1016/j.cyto.2018.10.012

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