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Front Cell Neurosci. 2018 Nov 27;12:432. doi: 10.3389/fncel.2018.00432. eCollection 2018.

Astrocytes' Contribution to Adult Neurogenesis in Physiology and Alzheimer's Disease.

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1
Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.

Abstract

Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression. Interestingly, adult neurogenesis is tightly regulated by the neurogenic niche, which provides a structural and molecular scaffold for stem cell proliferation and the differentiation and functional integration of new neurons. In this review, we highlight the role of astrocytes in the regulation of adult neurogenesis in the context of cognitive function. We also discuss how the changes in astrocytes function may dysregulate adult neurogenesis and contribute to cognitive impairment in the context of Alzheimer's disease.

KEYWORDS:

Alzheimer’s disease; astrocytes; neurogenesis; neurogenic niche; secretion

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