Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2019 Jan 15;508(3):871-876. doi: 10.1016/j.bbrc.2018.12.034. Epub 2018 Dec 8.

Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise.

Author information

1
Department of Nutrition, Food and Exercise Science, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA.
2
Department of Nutrition, Food and Exercise Science, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA.
3
Department of Nutrition, Food and Exercise Science, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA. Electronic address: bsgordon@fsu.edu.

Abstract

Exercise increases skeletal muscle health in part by altering the types of genes that are transcribed. Previous work suggested that glucocorticoids signal through the protein Regulated in Development and DNA Damage 1 (REDD1) to regulate gene expression following acute aerobic exercise. The present study shows that expression of the core clock gene, Period1, is among those modulated by the glucocorticoid-REDD1 signaling pathway in skeletal muscle. We also provide evidence that Aldosterone and Epinephrine contribute to the regulation of Period1 expression via REDD1. These data show that adrenal stress hormones signal through REDD1 to regulate skeletal muscle gene expression, specifically those of the core clock, following acute aerobic exercise.

KEYWORDS:

Aldosterone; Epinephrine; Glucocorticoids

PMID:
30538043
DOI:
10.1016/j.bbrc.2018.12.034

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center