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Stem Cells Transl Med. 2019 Apr;8(4):375-382. doi: 10.1002/sctm.18-0155. Epub 2018 Dec 11.

Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair.

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The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.


All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano-, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. Stem Cells Translational Medicine 2019;8:375-382.


Angiogenesis; Cell adhesion molecules; Cell interactions; Endothelial cell; Glycosaminoglycan; Induced pluripotent stem cells; Microvasculature; Tissue regeneration

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